2-[(2-ISOPROPYL-5-METHYLCYCLOHEXYL)OXY]ACETIC ACID
(-)-MENTHOXYACETIC ACID
CAS: 40248-63-3
Molecular Formula: C12H22O3
2-[(2-ISOPROPYL-5-METHYLCYCLOHEXYL)OXY]ACETIC ACID - Names and Identifiers
2-[(2-ISOPROPYL-5-METHYLCYCLOHEXYL)OXY]ACETIC ACID - Physico-chemical Properties
| Molecular Formula | C12H22O3 |
| Molar Mass | 214.3 |
| Density | 1.01 g/mL at 20 °C(lit.) |
| Melting Point | 52-55 °C(lit.) |
| Boling Point | 163-164 °C10 mm Hg(lit.) |
| Flash Point | >230 °F |
| Appearance | Form liquid, color yellow |
| pKa | 3.47±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | n20/D 1.4672(lit.) |
| MDL | MFCD00001483 |
| Physical and Chemical Properties | Chemical properties Melting point 52-55 ℃, boiling point 163-164 ℃(1.33kPa), refractive index (nD20)1.4672, relative density 1.020. |
| Use | Uses for organic synthesis intermediates. |
2-[(2-ISOPROPYL-5-METHYLCYCLOHEXYL)OXY]ACETIC ACID - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29189900 |
2-[(2-ISOPROPYL-5-METHYLCYCLOHEXYL)OXY]ACETIC ACID - Upstream Downstream Industry
| Raw Materials | L-Menthol |
| Downstream Products | Acemetacin (-)-MENTHOXYACETYL CHLORIDE |
2-[(2-ISOPROPYL-5-METHYLCYCLOHEXYL)OXY]ACETIC ACID - Nature
| optical activity (optical activity) | [α]25/D 92.5°, c = 4 in methanol |
| BRN | 2444474 |
Last Update：2024-04-10 22:29:15
2-[(2-ISOPROPYL-5-METHYLCYCLOHEXYL)OXY]ACETIC ACID - Production method
400g(2.56mol) menthol is dissolved in 1L toluene, 70g(3.04mol) sodium metal is added, heated and refluxed for 15h to remove excess sodium, 95g(1.01mol) chloroacetic acid is added dropwise in 800ml toluene solution, after addition, stirred and refluxed for 48h. The reaction mixture is extracted with water, the extract is acidified with 20% hydrochloric acid, and the crude oxyacetic acid forms brown oil and accumulates in the upper part. The crude product can be purified by vacuum distillation to obtain 166-180g of product with a yield of 78%-84%.
Last Update：2024-04-10 22:29:15
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Raw Materials for 2-[(2-ISOPROPYL-5-METHYLCYCLOHEXYL)OXY]ACETIC ACID
Downstream Products for 2-[(2-ISOPROPYL-5-METHYLCYCLOHEXYL)OXY]ACETIC ACID